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Sertraline and mirtazapine do not help patients with Alzheimer's and depression

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The antidepressants sertraline and mirtazapine provide no benefit for patients with Alzheimer’s and depression, according to a UK study of 300 patients with both conditions.

The patients were divided into three groups, receiving either sertraline, mirtazapine or a placebo. Decreases in depression symptoms between the groups were no different after 39 weeks.

The authors said the two drugs should be “reconsidered” as first-line treatments for depression in Alzheimer’s.

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Readers' comments (1)

  • michael stone

    I have recently been told, elsewhere, that the interactions between bagfuls of prescribed medication are well-understood (I am cynical).

    The fact that every so often, someone seems to prove that an accepted treatment is completely useless, does nothing to decrease my cynicism !

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