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SSRIs linked with bone fracture

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DAILY use of selective serotonin reuptake inhibitors (SSRIs) has been linked to an increased risk of fracture in older people, a new study has found.

DAILY use ofselective serotonin reuptake inhibitors (SSRIs) has been linked to an increased risk of fracture in older people, a new study has found.

The Canadian study evaluated over 5,000 adults aged 50 years and older and examined the relationships between SSRI use, bone mineral density and falls. Daily use of SSRIs was reported by 137 participants whose average age was 65.1 years.

The researchers found that daily SSRI use remained associated with a 'two-fold increased risk of incident clinical fragility fracture'. These fractures occurred at the forearm, ankle and foot, hip, rib, femur and back.

The authors said: 'In light of the high rate of SSRI use among the general population, and among elderly persons in particular, further studies that include controlled prospective trials are needed to confirm our findings.'

Arch Intern Med.2007;167:188-194

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