Yeast infections caused by candidemia respond better to treatment with single-drug antifungal prophylaxis (SAP) than a multi-drug regimen of selective digestive tract decontamination (SDD), say Dutch researchers.
They reviewed data from 33 studies, involving 5,500 patients. The incidence of candidemia was reduced by SAP but not by SDD, the authors said. However, in-hospital mortality was found to be reduced predominantly by SDD.
‘Systemic drugs may be advised as prophylaxis in patients with a high risk of developing Candida bloodstream infections, whereas SDD may be given to critically ill patients,’ they said.
Critical Care (2007) 11: R126